Oncologic Outcomes for Squamous Cell Carcinoma In Situ With a Clinically Resolved Biopsy Site Managed by Watchful Waiting
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View abstract on PubMed
Summary
This summary is machine-generated.Watchful waiting for squamous cell carcinoma in situ (SCCIS) shows a 4% local recurrence rate. Solid-organ transplant recipients and specific tumor locations/biopsy features increase recurrence risk.
Area Of Science
- Dermatology
- Oncology
- Surgical Pathology
Background
- Treatment decisions for low-risk squamous cell carcinoma in situ (SCCIS) lack management-specific outcomes data.
- SCCIS management often involves active treatment, but non-invasive approaches require further investigation.
Purpose Of The Study
- To evaluate tumor outcomes for SCCIS managed with watchful waiting.
- To identify risk factors associated with poor outcomes in SCCIS patients managed non-operatively.
Main Methods
- Retrospective cohort study of adult SCCIS patients diagnosed between 2014-2016 at a single academic hospital.
- Analysis of local recurrence (LR), nodal metastases (NM), distant metastases (DM), and disease-specific death (DSD).
- Multivariate analysis to determine hazard ratios (HRs) for identified risk factors.
Main Results
- Of 411 SCCIS tumors managed with watchful waiting, 17 (4%) experienced local recurrence; no NM, DM, or DSD were observed.
- Solid-organ transplant recipient status was the strongest predictor of LR (HR, 9.979).
- Additional LR risk factors included tumor location on the vermilion lip or ear (HR, 9.744), head and neck (HR, 6.687), and deep biopsy margins (HR, 6.562).
Conclusions
- Watchful waiting is a viable management strategy for SCCIS with a clinically resolved biopsy site, yielding a 4% local recurrence rate.
- Identifying high-risk patients (e.g., transplant recipients, specific tumor locations) is crucial for tailoring SCCIS management.
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