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Updated: Jun 26, 2025
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Transcanalicular Diode Laser-assisted Dacryocystorhinostomy for the Treatment of Primary Acquired Nasolacrimal Duct Obstruction
Published on: October 13, 2017
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Lacrimal Obstruction in Craniosynostosis: Anatomical and Genetic Risk Factors
Daphna Landau-Prat1,2,3,4, Jesse A Taylor5, Christopher L Kalmar5
1Division of Ophthalmology, Children's Hospital of Philadelphia.
Ophthalmic Plastic and Reconstructive Surgery
|May 9, 2024
Summary
Patients with craniosynostosis have a higher incidence of nasolacrimal duct obstruction (NLDO). Genetic or syndromic conditions and female sex are identified as key risk factors for NLDO in these patients.
Area of Science:
- Ophthalmology
- Craniofacial Surgery
- Genetics
Background:
- Craniosynostosis is a condition involving the premature fusion of skull sutures.
- Nasolacrimal duct obstruction (NLDO) is a common ophthalmic condition.
- The relationship between craniosynostosis and NLDO requires further investigation.
Purpose of the Study:
- To determine if patients with craniosynostosis have increased rates of NLDO.
- To identify potential risk factors associated with NLDO in craniosynostosis patients.
Main Methods:
- A retrospective review of craniosynostosis patients treated between 2009 and 2020.
- Data collected included synostosis characteristics, lacrimal disorders, and genetic information.
- Outcome measures focused on NLDO prevalence and its association with risk factors.
Main Results:
- 6.2% of craniosynostosis patients presented with NLDO.
- NLDO was significantly more prevalent in patients with syndromic/genetic associations (11.0%) compared to non-syndromic patients (3.5%).
- Apert syndrome and genetic variants EFNB1 and FGFR2 were associated with higher NLDO rates.
Conclusions:
- Nasolacrimal duct obstruction is more frequent in craniosynostosis patients.
- Syndromic/genetic factors and female sex are risk factors for NLDO.
- Ophthalmic evaluations are recommended for all craniosynostosis patients.
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