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Updated: Jun 26, 2025

High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays
Published on: July 17, 2014
Declining Antibody Affinity Over Time After Human Vaccination With a Plasmodium falciparum Merozoite Vaccine
Kristina E M Persson1,2, Jessica L Horton3, Liriye Kurtovic3
1Department of Laboratory Medicine, Lund University, Lund, Sweden.
Abstract:
Maintaining high-affinity antibodies after vaccination may be important for long-lasting immunity to malaria, but data on induction and kinetics of affinity is lacking. In a phase 1 malaria vaccine trial, antibody affinity increased following a second vaccination but declined substantially over 12 months, suggesting poor maintenance of high-affinity antibodies.
Clinical Trials Registration:
Australian New Zealand Clinical Trials Registry ACTRN12607000552482.
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