Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

76
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
76

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

KRAS inhibition is an effective therapy for appendiceal adenocarcinoma.

Journal of hematology & oncology·2026
Same author

Intrahepatic cholangiocarcinoma treated with glass yttrium-90 radioembolization: A histopathologic study.

European journal of nuclear medicine and molecular imaging·2026
Same author

Evaluating the Risk of <i>Clostridioides difficile</i> Infection After Rifaximin Treatment for Small Intestinal Bacterial Overgrowth.

Journal of clinical medicine·2026
Same author

Selective Organ Site Strategy Versus Debulking in Multiorgan Metastatic Colorectal Cancer: Lessons from the ORCHESTRA Trial.

Annals of surgical oncology·2026
Same author

Safety of Live Attenuated MMR, Varicella, and Yellow Fever Vaccination in Patients with Inflammatory Bowel Disease Receiving Biologic and Targeted Synthetic Therapy: A Propensity-Score-Matched Analysis.

Vaccines·2026
Same author

ASO Visual Abstract: Survival Outcomes in Early-Onset Appendiceal Adenocarcinoma (EOAA).

Annals of surgical oncology·2026

Related Experiment Video

Updated: Jun 26, 2025

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.2K

Multi-Institutional Study Evaluating the Role of Circulating Tumor DNA in the Management of Appendiceal Cancers.

Erika Belmont1, Varun V Bansal2, Mahmoud M G Yousef3

  • 1Department of Medicine, Section of Hematology/Oncology, University of Chicago Medical Center, Chicago, IL.

JCO Precision Oncology
|May 9, 2024
PubMed
Summary
This summary is machine-generated.

Circulating tumor DNA (ctDNA) shows reduced detection after systemic therapy for appendiceal cancer (AC). ctDNA accurately detects recurrence after surgery, highlighting its role in managing AC.

More Related Videos

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
06:53

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

8.6K
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

5.5K

Related Experiment Videos

Last Updated: Jun 26, 2025

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.2K
Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
06:53

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

8.6K
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

5.5K

Area of Science:

  • Oncology
  • Molecular Diagnostics
  • Cancer Biomarkers

Background:

  • Appendiceal cancer (AC) surveillance is challenging due to low sensitivity of conventional methods.
  • Circulating tumor DNA (ctDNA) offers a potential non-invasive approach for monitoring cancer.
  • Evaluating ctDNA's utility in AC systemic therapy response and recurrence detection is crucial.

Purpose of the Study:

  • To investigate the role of ctDNA in assessing systemic therapy response in AC patients.
  • To evaluate the accuracy of ctDNA for detecting recurrence after cytoreductive surgery (CRS) in AC.
  • To compare ctDNA performance against traditional biomarkers for AC recurrence.

Main Methods:

  • Tumor-informed ctDNA testing (Signatera) was performed on 94 AC patients from two centers.
  • Association between systemic therapy and ctDNA detection was analyzed.
  • ctDNA accuracy for recurrence detection post-CRS in grade 2-3 AC with peritoneal metastases (PM) was assessed.

Main Results:

  • ctDNA was detected in 57.1% (grade 1), 62.5% (grade 2), and 70.4% (grade 3) of patients with detectable disease.
  • Chemotherapy reduced ctDNA detection frequency (43.8% vs. 76.5%, P = .02).
  • In 36 patients post-CRS, ctDNA accurately detected recurrence (93.8% sensitivity, 85.0% specificity), predicting shorter recurrence-free survival (HR 14.1, P = .01).

Conclusions:

  • Reduced ctDNA detection after systemic therapy suggests its utility in monitoring treatment response.
  • ctDNA demonstrates high accuracy in detecting recurrence after CRS for AC-PM.
  • ctDNA serves as a valuable predictive and prognostic biomarker for managing advanced AC.