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Preparation of Functional Silica Using a Bioinspired Method
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A universal strategy for constructing high-performance silica-based AIE materials for biomedical application.

Yu Zhang1, Runjie Miao1, Haifeng Sha2

  • 1State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai 200050, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049, China.

Journal of Colloid and Interface Science
|May 9, 2024
PubMed
Summary

This study introduces a novel method using hydrophobic dendritic mesoporous silica (HMSN) to create stable, multi-color aggregation-induced emission luminogen (AIEgen) materials. These AIEgens enable sensitive detection of biomarkers like cardiac troponin I and cell quantification.

Keywords:
Aggregation-induced emissionBiomedical applicationsBright and stableCardiac troponin IHydrophobic dendritic silica

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Aggregation-induced emission luminogens (AIEgens) show promise but suffer from poor water solubility and fluorescence stability.
  • Existing AIEgens face limitations in complex biological environments, hindering practical applications.

Purpose of the Study:

  • To develop a universal strategy for creating stable, multi-color fluorescent AIE materials.
  • To overcome the limitations of traditional AIEgens for enhanced biosensing and bioimaging applications.

Main Methods:

  • Utilized hydrophobic dendritic mesoporous silica (HMSN) as a carrier for AIE molecules, restricting intramolecular motion.
  • Engineered silica-based AIE materials with high quantum yield and stability.
  • Conjugated materials with antibodies and integrated with immunomagnetic beads for detection probes.

Main Results:

  • Achieved bright fluorescence (max quantum yield 68.38%) with high colloidal and fluorescence stability.
  • Demonstrated excellent biosafety of the developed silica-based AIE materials.
  • Successfully quantified cardiac troponin I (LOD 0.508 ng/mL) and Jurkat cells (LOD 270 cells/mL) using the probes.

Conclusions:

  • The developed HMSN-based AIE materials offer a robust platform for advanced fluorescent probes.
  • These probes facilitate sensitive disease biomarker detection and cell quantification for etiological determination.
  • The strategy provides a versatile approach for designing next-generation AIE-based diagnostic tools.