Precision medicine in Sjögren's disease

Area of Science:

• Autoimmune diseases
• Clinical immunology
• Precision medicine

Background:

• Sjögren's disease exhibits significant clinical and pathophysiological heterogeneity.
• The link between biological pathways and symptoms like fatigue and pain is often unclear.
• This dissociation complicates the establishment of effective clinical trial endpoints.

Purpose of the Study:

• To review current evidence on stratifying Sjögren's disease.
• To explore how stratification can guide precision medicine.
• To inform the design of future clinical trials.

Main Methods:

• Review of clinical, laboratory, histological, and biomolecular stratification data.
• Analysis of patient clustering into homogenous subgroups.
• Examination of molecular signatures, biomarkers, and clinical features.

Main Results:

• Development of stratification models for Sjögren's disease.
• Identification of distinct patient subgroups with unique molecular profiles.
• Evidence supporting the application of stratification in clinical practice.

Conclusions:

• Stratification is crucial for understanding Sjögren's disease heterogeneity.
• Stratification models can enhance precision medicine approaches.
• This approach is vital for designing more effective clinical trials.