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Mapping the Human Cell Surface Interactome: A Key to Decode Cell-to-Cell Communication.
Jarrod Shilts1,2, Gavin J Wright1
1Department of Biology, Hull York Medical School, York Biomedical Research Institute, University of York, York, United Kingdom;
Annual Review of Biomedical Data Science
|May 9, 2024
Summary
Understanding the human cell surface protein interactome is crucial for cell communication and multicellular organization. This review maps current knowledge and remaining gaps in cell surface protein interactions.
Area of Science:
- Cellular Biology
- Biochemistry
- Bioinformatics
Background:
- Cell surface proteins mediate intercellular communication and tissue structure.
- Understanding these interactions is vital for advancing multicellular biology and clinical applications.
- A comprehensive map of cell surface protein interactions is needed.
Purpose of the Study:
- To assess the current state of knowledge regarding the human cell surface protein interactome.
- To identify existing databases and technologies for mapping these interactions.
- To highlight significant gaps in the current interactome data.
Main Methods:
- Literature review of existing databases and systematic technologies.
- Analysis of current methodologies for identifying cell surface protein interactions.
- Assessment of the completeness of the human cell surface protein interactome.
Main Results:
- Databases and technologies for assembling cell surface protein interactomes are available but incomplete.
- Substantial gaps exist in our understanding of the full human cell surface protein interactome.
- Current efforts provide a partial view of protein-protein interactions on cell surfaces.
Conclusions:
- A comprehensive understanding of the human cell surface protein interactome is not yet achieved.
- Further systematic efforts are required to build a robust map of these interactions.
- This review serves as a roadmap for future research in the field.
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