Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

1.3K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.3K
Coronary Circulation01:21

Coronary Circulation

2.6K
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
2.6K
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

644
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
644

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Current Advances and Navigating the Complexities of SVG-PCI.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2026
Same authorSame journal

Marijuana Use and Acute Myocardial Infarction: Mechanistic Insights, Clinical Implications, and Emerging Challenges.

The American journal of medicine·2026
Same author

Financial Toxicity: Inequities and Impact on Cardiovascular Disease.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

Septic cardiomyopathy: Fact or fiction?

American heart journal plus : cardiology research and practice·2026
Same author

Infective Endocarditis: A Contemporary Review of Epidemiology, Diagnosis, and Management.

Antibiotics (Basel, Switzerland)·2026
Same author

Highlights of Cardiovascular Disease Prevention Studies Presented at the 2026 American College of Cardiology Conference.

Current atherosclerosis reports·2026
Same journal

Mineralocorticoid Antagonists for Post-MI HFpEF: Plausible Biology Meets Low Residual Risk?

The American journal of medicine·2026
Same journal

GLP-1 Receptor Agonists and Age-related Macular Degeneration Risk in Diabetes or Non-diabetic Obesity: A Retrospective Cohort Study.

The American journal of medicine·2026
Same journal

Cave Canem - Beware of the Dog.

The American journal of medicine·2026
Same journal

Risk Factors for 30-day Hospital Readmission After Hospital-at-Home Treatment of Acute Pyelonephritis.

The American journal of medicine·2026
Same journal

Mesenteric panniculitis.

The American journal of medicine·2026
See all related articles

Related Experiment Video

Updated: Jun 26, 2025

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

2.4K

Coronary Microvascular Dysfunction: A Guide for Clinicians.

Hannah Smati1, Frank W Sellke2, Jamieson M Bourque3

  • 1Department of Medicine, Baylor College of Medicine, Houston, Texas.

The American Journal of Medicine
|May 9, 2024
PubMed
Summary
This summary is machine-generated.

Coronary microvascular dysfunction causes myocardial ischemia in patients without blockages. This review clarifies its causes, diagnosis, and limited treatment options for better patient care.

Keywords:
CMDCoronary flow reserveCoronary microvascular dysfunctionIndex of Microcirculatory Resistance

More Related Videos

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations
08:21

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

1.3K
Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

4.9K

Related Experiment Videos

Last Updated: Jun 26, 2025

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

2.4K
Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations
08:21

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

1.3K
Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

4.9K

Area of Science:

  • Cardiology
  • Vascular Biology
  • Myocardial Pathophysiology

Background:

  • Coronary microvascular dysfunction (CMD) is increasingly recognized as a cause of myocardial ischemia, particularly in patients without obstructive coronary artery disease (CAD).
  • Understanding of CMD pathophysiology and management is limited, often relying on data extrapolated from epicardial CAD.
  • Accurate diagnosis and targeted therapies for CMD are crucial but remain challenging.

Purpose of the Study:

  • To review the current understanding of the pathophysiology of coronary microvascular dysfunction.
  • To summarize diagnostic techniques for assessing CMD.
  • To evaluate existing management strategies for CMD.

Main Methods:

  • Literature review focusing on pathophysiology, diagnosis, and management of CMD.
  • Analysis of studies involving myocardial blood flow and flow reserve quantification.
  • Appraisal of clinical data specific to CMD patients.

Main Results:

  • CMD is a significant contributor to myocardial ischemia in non-obstructive CAD.
  • Diagnostic tools like myocardial blood flow quantification have improved, but gaps remain.
  • Evidence-based management options for CMD are scarce.

Conclusions:

  • Further research is needed to elucidate CMD pathophysiology and develop targeted treatments.
  • Improved diagnostic accuracy is essential for timely intervention in CMD.
  • Specific management guidelines for CMD are required to optimize patient outcomes.