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Peptide libraries: from epitope mapping to in-depth high-throughput analysis

Debora Iaculli1, Steven Ballet1

  • 1Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, B-1050 Brussels, Belgium.

Trends in Pharmacological Sciences
|May 9, 2024
PubMed

Peptide arrays are a valuable instrument in the characterization of protein-protein interactions (PPIs) and immunogenic regions. New methods were developed to exploit the high-throughput potential of peptide arrays to obtain more in-depth information, replacing traditional resource-intensive experiments. Here, we discuss the recent advances in peptide-array-based technologies and the remaining challenges.

Keywords:
epitope mappingpeptide arrayspeptide librariespeptide scanningprotein–protein interactions

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