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Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR
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Human adenoviruses in children with gastroenteritis: a systematic review and meta-analysis

Pegah Khales1, Mohammad Hossein Razizadeh2,3, Saied Ghorbani1

  • 1Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

BMC Infectious Diseases
|May 9, 2024
PubMed

Insights

Human adenoviruses (HAdVs) cause 10% of childhood gastroenteritis globally, particularly in younger and hospitalized children. Species F, including types 40/41, 38, and 2, are most common, highlighting the need for preventive strategies.

Area of Science:

  • Virology
  • Pediatrics
  • Epidemiology

Background:

  • Human adenoviruses (HAdVs) are implicated in pediatric gastroenteritis.
  • A comprehensive global epidemiological report on HAdVs in children was lacking.

Approach:

  • Systematic literature search (2003-2023) across PubMed, Scopus, and Web of Science.
  • Pooled prevalence and meta-analysis of case-control studies were performed.

Key Points:

  • Global pooled prevalence of HAdV in pediatric gastroenteritis is 10%, with a rising trend post-2010.
  • Africa shows the highest prevalence (20%). Higher rates observed in inpatients and children ≤5 years old.
  • HAdV species F (types 40/41, 38, 2) are most prevalent; HAdV infection is associated with increased gastroenteritis risk (OR 2.28).

Conclusions:

  • HAdVs are significant contributors to pediatric gastroenteritis, especially in vulnerable groups.
  • Findings underscore the importance of HAdVs in disease burden and inform future vaccine development and public health interventions.
Abstract

Keywords:
ChildrenEpidemiologyGastroenteritisHuman adenovirusesPediatrics

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