Related Experiment Video

Updated: Jun 26, 2025

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.2K

Cancer Clinical Trials: Advancing Care, Inspiring Hope

Sohilkhan R Pathan1, Nirav Asarawala2, Kruti B Sharma1

  • 1Clinical Research Services (CRS), Bhanubhai and Madhuben Patel Cardiac Centre, Shree Krishna Hospital and Medical Research Centre, Bhaikaka University, Anand, IND.

Cureus
|May 10, 2024
PubMed

Insights

Cancer clinical trials advance medical progress and patient care, yet low participation rates highlight significant recruitment barriers. Overcoming these challenges is crucial for future cancer research and treatment innovation.

Area of Science:

  • Oncology
  • Clinical Research
  • Translational Medicine

Background:

  • Cancer clinical trials are crucial for advancing medical treatments and improving patient outcomes.
  • Less than 5% of adult cancer patients currently participate in clinical trials, indicating substantial recruitment and engagement obstacles.

Discussion:

  • Clinical trials serve as critical platforms for scientific innovation, fostering exploration and patient empowerment.
  • They drive advancements in treatment modalities, supportive care, and survivorship strategies, addressing diverse patient needs.
  • Emphasis on diversity and inclusivity ensures treatment relevance across demographics and promotes health equity.

Key Insights:

  • Low patient participation in cancer clinical trials presents a significant barrier to medical progress.
  • Clinical trials are essential for developing novel therapies and improving cancer care.
  • Adaptability of trials, demonstrated during the COVID-19 pandemic, highlights their resilience.

Outlook:

  • Addressing recruitment and engagement challenges is vital to increase participation in cancer clinical trials.
  • Continued commitment to patient and researcher contributions will propel cancer science forward.
  • Enhancing clinical trial participation will reshape the future of cancer care globally.
Keywords:
cancer clinical trialsdiversity and inclusivitymedical advancementspatient outcomesrecruitment challenges

More Related Videos

Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications14:14

Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications

Published on: February 28, 2014

15.9K
Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization09:49

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization

Published on: December 2, 2013

10.3K

Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
2.9K
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
6.7K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
345
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.6K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
358