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Upper gastrointestinal bleeding in patients with chronic renal failure
Annals of Internal Medicine
|May 1, 1985
Summary
Patients with chronic renal failure experience different upper gastrointestinal bleeding causes and recurrence rates. Angiodysplasia is a key factor in this population, unlike those without renal failure.
Area of Science:
- Gastroenterology
- Nephrology
Background:
- Upper gastrointestinal bleeding (UGIB) is a common clinical problem.
- Chronic renal failure (CRF) may influence the etiology and outcomes of UGIB.
Purpose of the Study:
- To compare the causes and recurrence of UGIB in patients with and without CRF.
Main Methods:
- Retrospective analysis of 482 patients undergoing endoscopy for UGIB over 42 months.
- Patients were categorized into two groups: those with CRF (n=59) and those without CRF (n=423).
- Etiologies of bleeding and recurrence rates were compared between groups.
Main Results:
- Angiodysplasia was the most frequent UGIB source in CRF patients.
- Angiodysplasia and erosive esophagitis were significantly more common in CRF patients.
- Recurrent bleeding was more frequent in CRF patients (25%) compared to non-CRF patients (11%).
- Angiodysplasia caused recurrent bleeding in 53% of CRF patients, while peptic lesions predominated in non-CRF patients (51%).
Conclusions:
- The diagnostic approach to UGIB differs between patients with and without CRF.
- Angiodysplasia is a critical consideration for UGIB, especially recurrent bleeding, in patients with CRF.