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Related Experiment Videos

[High-dose treatment].

F Takaku

    Gan to Kagaku Ryoho. Cancer & Chemotherapy
    |April 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    High-dose methotrexate and cytosine arabinoside offer effective cancer treatment for resistant cases. Careful administration is crucial to manage potential side effects of these potent anticancer drugs.

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    [Present status and future aspects of clinical use of cytokines].

    Nihon rinsho. Japanese journal of clinical medicine·1992

    Area of Science:

    • Oncology
    • Pharmacology

    Context:

    • Anticancer drug resistance necessitates exploring alternative therapeutic strategies.
    • High-dose chemotherapy regimens are being investigated for challenging cancer cases.

    Purpose:

    • To review the efficacy and safety of high-dose methotrexate and cytosine arabinoside.
    • To highlight their application in treating resistant and relapsed cancers.

    Summary:

    • High-dose methotrexate with leucovorin rescue shows efficacy against resistant cancers but requires careful monitoring for side effects like mucositis and hepatic dysfunction.
    • High-dose cytosine arabinoside, particularly in combination with anthracyclines or L-asparaginase, achieves high remission rates in acute leukemia, including initial treatment protocols.

    Impact:

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    • These high-dose regimens provide viable options for patients with refractory or relapsed malignancies.
    • Successful initial treatment with high-dose cytosine arabinoside demonstrates potential for improved remission duration and survival rates.