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Oridonin from Rabdosia rubescens: An emerging potential in cancer therapy - A comprehensive review

Muhammad Asif Ali1, Noohela Khan2, Ahmad Ali1

  • 1Department of Food Science and Human Nutrition UVAS Lahore Pakistan.

Food Science & Nutrition
|May 10, 2024
PubMed

Insights

Oridonin (ORI), a plant compound, shows potential for cancer treatment by exhibiting antitumor properties. Research reviews ORI

Area of Science:

  • Phytochemistry
  • Pharmacology
  • Oncology

Background:

  • Rising global cancer incidence necessitates novel therapeutic strategies.
  • Current cancer treatments have invasive procedures and side effects.
  • Plant-derived compounds offer potential for reduced toxicity and improved cancer management.

Purpose of the Study:

  • To review the anticancer effectiveness of oridonin (ORI).
  • To explore the mechanisms underlying ORI's antitumor activities.
  • To provide insights into future applications of ORI in cancer therapy.

Main Methods:

  • Comprehensive literature review of studies on oridonin (ORI).
  • Analysis of research from 1976 to 2022.
  • Focus on ORI's effects on murine and human cancer models.

Main Results:

  • Oridonin (ORI) exhibits significant antitumor and antiangiogenesis properties.
  • ORI demonstrates anti-inflammatory and apoptosis-inducing effects.
  • Extensive research supports ORI's diverse anticancer mechanisms.

Conclusions:

  • Oridonin (ORI) is a promising plant-derived compound for cancer therapy.
  • ORI's multifaceted mechanisms warrant further investigation.
  • ORI holds potential for integration into future cancer treatment protocols.
Keywords:
ORIanticancer propertiescancer treatmentditerpenoidnatural compound

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