Risk factors for infliximab-induced infusion reactions based on a retrospective study of medical information
Objective:
Infliximab is indicated for a wide range of diseases, and infusion reactions (IRs) have been reported after infliximab administration in 17.6% of patients in clinical practice. This study aimed to identify the risk factors for IRs before the administration of infliximab based on available patient information.
Materials And Methods:
We retrospectively analyzed patients treated with infliximab. Data were compared between patients with and without IRs immediately before initiation of infliximab.
Results:
Elevated C-reactive protein (CRP) (odds ratio (OR), 2.150; 95% confidence interval (CI), 1.329 - 3.477; p = 0.002) before infliximab administration was a significant risk factor for developing an IR.
Conclusion:
Patients with elevated CRP levels before therapy initiation may require more careful monitoring after infliximab administration.
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