Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Standards of Care II01:19

Standards of Care II

Nurses bear specific legal responsibilities under several federal statutes, including:
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neurodevelopmental impairment in infants with necrotizing enterocolitis: a comprehensive review of mechanisms, outcomes, and emerging strategies.

World journal of pediatric surgery·2026
Same author

Parental Anxiety Trajectories 2 Years After NICU Discharge.

Pediatrics·2026
Same author

Intussusception in Neonates: Uncommon Causes and Diagnostic Dilemmas in Two Case Reports.

Case reports in gastroenterology·2026
Same author

Multimodal neuromonitoring in neonatal hypoxic-ischemic encephalopathy and the association with neurodevelopmental outcomes: A Multicenter Study.

The Journal of pediatrics·2026
Same author

Inter-Rater Reliability Of Assigning A Pediatric Appendicitis Grade: An International Multicenter Study By The Canadian Consortium For Research In Pediatric Surgery (CanCORPS).

Annals of surgery open : perspectives of surgical history, education, and clinical approaches·2026
Same author

Malignant transformation of sacrococcygeal teratoma versus presacral teratoma in Currarino syndrome: Results of 'The SCT-study'.

Journal of pediatric surgery·2026

Related Experiment Video

Updated: Jul 18, 2026

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
08:42

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

Published on: April 10, 2019

7.7K

Core Outcome Set for Necrotizing Enterocolitis Treatment Trials.

Daphne H Klerk1, Otis C van Varsseveld2, Martin Offringa3

  • 1Division of Neonatology, Beatrix Children's Hospital.

Pediatrics
|May 10, 2024
PubMed
Summary

A new core outcome set (COS) for necrotizing enterocolitis (NEC) treatment trials was developed. This standardized approach ensures patient- and physician-relevant outcomes are consistently reported, improving NEC care.

More Related Videos

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis
09:11

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

Published on: June 8, 2022

2.2K
Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model
06:51

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Published on: July 28, 2023

1.2K

Related Experiment Videos

Last Updated: Jul 18, 2026

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
08:42

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

Published on: April 10, 2019

7.7K
In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis
09:11

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

Published on: June 8, 2022

2.2K
Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model
06:51

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Published on: July 28, 2023

1.2K

Area of Science:

  • Neonatal Medicine
  • Pediatric Surgery
  • Clinical Trial Methodology

Background:

  • Necrotizing enterocolitis (NEC) treatment trials exhibit significant variability in outcome reporting.
  • This inconsistency impedes meta-analyses and the implementation of novel therapeutic strategies.
  • Standardized outcome reporting is crucial for advancing NEC research and clinical practice.

Purpose of the Study:

  • To develop a consensus-based core outcome set (COS) for necrotizing enterocolitis (NEC) treatment trials.
  • The COS aims to encompass outcomes most relevant to patients and physicians, from diagnosis through adulthood.
  • This initiative seeks to standardize outcome measurement in NEC clinical research.

Main Methods:

  • A systematic review identified 45 potential outcomes for NEC research.
  • Three online Delphi rounds involving clinicians, researchers, patients, and parents were conducted for consensus building.
  • A final consensus meeting with international stakeholders, including patients and family representatives, finalized the outcome set.

Main Results:

  • Seventy-one participants from 25 countries, including 15 patient/family representatives, completed the Delphi rounds.
  • Thirteen outcomes achieved consensus in at least one stakeholder group; 6 reached consensus in both.
  • Five outcomes were selected: mortality, NEC-related mortality, short bowel syndrome, quality of life, and neurodevelopmental impairment.

Conclusions:

  • An international core outcome set (COS) for NEC treatment trials has been established, comprising 5 key outcomes.
  • This COS, agreed upon by clinicians, patients, and families, focuses on predominantly long-term results.
  • Implementation of this COS will standardize outcome selection, enhance trial relevance, and ultimately improve infant care for NEC.