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Methods and clinical biomarker discovery for targeted proteomics using Olink technology

Han Wang1,2, Tian Zhao1,2, Jingjing Zeng1,2

  • 1Department of Clinical Epidemiology, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.

Proteomics. Clinical Applications
|May 10, 2024
PubMed
Abstract

Insights

This study explores Olink technology for identifying disease biomarkers and therapeutic targets. It highlights Olink

Area of Science:

  • Proteomics and Biomarker Discovery
  • Translational Research in Disease Treatment

Background:

  • Olink technology offers a powerful platform for high-throughput proteomic analysis.
  • Understanding disease pathogenesis requires comprehensive proteomic insights.

Purpose of the Study:

  • To provide guidance for research design using Olink technology.
  • To identify novel biomarkers and therapeutic targets for various diseases.

Main Methods:

  • Discussion of Olink technology applications in oncology, cardiovascular, respiratory, and immune-related diseases.
  • Analysis of the advantages and limitations of Olink technology.

Main Results:

  • Olink technology streamlines the identification of therapeutic targets.
  • Facilitates advancements in proteomics research and disease pathogenesis elucidation.
  • Supports the development of precision treatments for patients.

Conclusions:

  • While Olink technology is advanced, complementary methods are crucial for validation.
  • Future research should integrate multiple proteomic approaches for robust findings.
Keywords:
Olink technologybiomarkersdisease researchpanelproximity extension assay

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