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Drawing human pedigree charts with DrawPed.

Janina Schönberger1,2, Robin Steinhaus1,2, Dominik Seelow1,2

  • 1Exploratory Diagnostic Sciences, Berliner Institut für Gesundheitsforschung@Charité, Charitéplatz 1, 10117, Berlin, Germany.

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Summary

DrawPed is a new, free, open-source tool for creating complex human pedigree charts. It simplifies the visualization of genetic relationships for biomedical research, offering both automated drawing and interactive editing features.

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Area of Science:

  • Biomedical Research
  • Genetics
  • Bioinformatics

Background:

  • Creating detailed human pedigree charts is essential for genetic research but often limited by a lack of accessible and free tools.
  • Existing software for pedigree analysis may be costly or lack advanced features for complex family structures.

Purpose of the Study:

  • To introduce DrawPed, a novel, free, and open-source software designed for the creation and editing of complex human pedigree charts.
  • To address the gap in readily available online tools for generating publication-ready pedigree visualizations.

Main Methods:

  • DrawPed processes standard PED format files to automatically generate pedigree charts.
  • The software allows users to create pedigrees de novo and interactively edit existing charts.
  • It supports the display of additional phenotypic information, such as deceased status and consanguinity, beyond standard PED file data.

Main Results:

  • DrawPed successfully generates scalable, publication-ready pedigree charts in SVG format.
  • The tool facilitates the export of pedigrees back into PED file format for data exchange and further analysis.
  • It provides an intuitive interface for both automated chart generation and manual editing of complex family structures.

Conclusions:

  • DrawPed offers a valuable, free, and open-source solution for researchers needing to create and visualize complex human pedigrees.
  • The software enhances the process of genetic data representation, aiding in biomedical research and genetic counseling.
  • Its features promote data sharing and integration with other bioinformatics tools.