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Association Between Family History and Early-Onset Atrial Flutter Across Racial and Ethnic Groups
Anish S Shah1,2, Ana Ongtengco1, Victor Qiao3
1Division of Cardiology, Department of Medicine University of Illinois Chicago Chicago IL.
Journal of the American Heart Association
|May 10, 2024
Summary
A family history of atrial tachyarrhythmias increases the risk of early-onset atrial flutter (EOAFL). This study highlights potential hereditary factors contributing to EOAFL across diverse populations.
Area of Science:
- Cardiology
- Genetics
- Epidemiology
Background:
- Genetic factors in early-onset atrial fibrillation are mainly studied in European populations.
- The role of race and family history in early-onset atrial flutter (EOAFL) is not well understood.
Purpose of the Study:
- To investigate the association between family history and the occurrence of EOAFL.
- To explore racial and clinical risk factors associated with EOAFL.
Main Methods:
- A cross-sectional study enrolled 909 patients with atrial flutter (AFL) confirmed by ECG.
- Family history was assessed via questionnaires and interviews.
- Early-onset atrial flutter (EOAFL) was defined as AFL diagnosed before age 66.
Main Results:
- A positive family history was linked to a higher likelihood of EOAFL (OR, 1.8).
- Black race (OR, 2.1), alcohol use (OR, 1.6), and obstructive sleep apnea (OR, 1.9) were associated with increased odds of EOAFL.
- Use of certain heart medications was associated with lower odds of EOAFL.
Conclusions:
- Findings suggest a hereditary predisposition to EOAFL across different races and ethnicities.
- Further research into the genetic underpinnings of atrial flutter is warranted.
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