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Published on: January 26, 2024
Breast lymphomas: Clinical and pathological insights from a tertiary cancer care center in India
Neha Singh1, Sadaf Hayat1, Sujeet Kumar2
1Department of Pathology, HBCH and MPMMCC, Varanasi, Uttar Pradesh, India.
Background:
Breast lymphomas are a rare group of malignancies that are further subdivided into primary and secondary.
Aims:
To study the pathological and clinical course of breast lymphomas.
Materials And Methods:
This is a retrospective analysis of patients treated at our institute over a period of 4.5 years from September 2018 to February 2023. The details of all the patients diagnosed with breast lymphoma were reviewed and analysed for the histomorphological, immunohistochemical, clinical, and treatment details. Appropriate statistical analysis including Kaplan-Meier methods was used.
Results:
Out of 11 cases of breast lymphoma, five were primary and six were secondary. It was seen predominantly in females (82%) and the age range was 31 to 73 years. Diffuse large B cell lymphoma (DLBCL) was the predominant morphology (73%), along with single rare cases of ALK-negative anaplastic large cell lymphoma, Burkitt lymphoma, and small lymphocytic lymphoma. The treatment details were analyzed for 7 patients. The median follow-up was 28 months. Rituximab along with CHOP regimen or its variants was commonly used as first-line treatment with initial response rates of 71%. The median progression-free survival was 5 months. The median overall survival was 15 months.
Conclusion:
Lymphomas of the breast are rare but it is crucial to differentiate them from the commoner breast carcinomas as the treatment and prognosis vary vastly.
