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Stereoselective macrocyclization reactions create complex organic molecules by forming new stereogenic centers. This summary highlights recent advances in natural product synthesis using these powerful asymmetric induction strategies.

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Area of Science:

  • Organic Chemistry
  • Synthetic Chemistry
  • Medicinal Chemistry

Background:

  • Macrocyclization reactions are crucial for synthesizing complex organic molecules.
  • Stereoselective synthesis is key to creating structurally and functionally diverse compounds.
  • Natural products and their analogues often feature macrocyclic structures.

Purpose of the Study:

  • To summarize recent advancements in macrocyclization reactions for organic synthesis.
  • To highlight the stereoselective creation of stereogenic centers during macrocyclization.
  • To review natural product and analogue syntheses employing macrocyclic disconnections.

Main Methods:

  • Review of recent literature on macrocyclization reactions.
  • Categorization of synthetic strategies based on asymmetric induction sources.
  • Analysis of both bioinspired and non-bioinspired macrocyclic disconnections.

Main Results:

  • Demonstrated utility of stereoselective macrocyclization in effective organic syntheses.
  • Compilation of diverse examples in natural product and analogue synthesis.
  • Organization of methods based on the origin of asymmetric induction.

Conclusions:

  • Stereoselective macrocyclization is a powerful strategy for complex molecule synthesis.
  • Recent progress offers diverse approaches to natural product and analogue construction.
  • Understanding asymmetric induction sources guides the development of new synthetic routes.