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Related Concept Videos

Tumor Progression02:07

Tumor Progression

6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
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  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. The Effect Of Intratumor Heterogeneity In Pancreatic Ductal Adenocarcinoma Progression And Treatment

The Effect of Intratumor Heterogeneity in Pancreatic Ductal Adenocarcinoma Progression and Treatment

Othman Saleh1, Hani Shihadeh2, Ahmad Yousef2

  • 1From the Faculty of Medicine, The Hashemite University, Zarqa.

Pancreas
|May 10, 2024

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Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
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Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

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Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma
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Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma

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View abstract on PubMed

Summary
This summary is machine-generated.

Pancreatic cancer remains lethal with unchanged survival rates. This review explores stem cells, genetic changes, and biomarkers for improved pancreatic cancer (PC) diagnosis and treatment.

Area of Science:

  • Oncology
  • Biomarker Discovery
  • Cancer Genetics

Background:

  • Pancreatic cancer (PC) exhibits dismal survival rates, unlike other major cancers.
  • A lack of cellular biomarker-based classification hinders PC treatment.
  • Stem cells and genetic alterations play crucial roles in PC progression.

Purpose of the Study:

  • To review the role of stem cells in pancreatic cancer progression.
  • To discuss genetic changes associated with pancreatic cancer.
  • To identify promising biomarkers for pancreatic cancer diagnosis.

Main Methods:

  • Literature search of PubMed, Cochrane Library, and Scopus databases.
  • Inclusion of relevant articles published in English.

Main Results:

Related Experiment Videos

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
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Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
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Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma
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Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma

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  • Cancer-associated fibroblast (CAF) diversity necessitates further research.
  • Common mutations (CDKN2, P53, K-RAS) are prevalent in pancreatic cancer.
  • Gene expression patterns and biomarkers can predict metastasis and drug resistance.

Conclusions:

  • Clearer classification is essential for optimizing pancreatic cancer treatment.
  • Understanding cancer-associated fibroblast roles is critical.
  • Exploring stroma-modifying strategies holds therapeutic promise.