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Related Experiment Video

Updated: Jun 26, 2025

Reverse Total Shoulder Arthroplasty

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Published on: July 5, 2011

Osteosarcoma After Total Knee Arthroplasty: A Case Report.

Pablo Martínez-Collado¹, Oriol Pujol², Andrés Bustos¹

¹Orthopedic Surgery Department, Vall d'Hebron University Hospital, Universitat Autónoma de Barcelona, Barcelona, Spain.

JBJS Case Connector

|May 10, 2024

Summary

A rare high-grade osteosarcoma developed around a total knee arthroplasty (TKA) in an elderly patient, leading to amputation. Early detection of aggressive implant loosening is crucial for managing this devastating complication.

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Area of Science:

Orthopedic Surgery
Oncology
Biomaterials Science

Background:

Periprosthetic fractures and implant loosening are known complications of total knee arthroplasty (TKA).
Malignant tumors arising around orthopedic implants are exceptionally rare, posing diagnostic and therapeutic challenges.

Observation:

A 79-year-old woman experienced a periprosthetic fracture 8 years post-TKA.
Radiographs revealed tibial implant loosening and severe osteolysis.
A diagnosis of high-grade osteosarcoma surrounding the prosthesis was confirmed.

Findings:

The patient underwent a supracondylar femoral amputation.
No complications were reported 2 years after the amputation.
This case highlights an unusual presentation of osteosarcoma in the context of TKA.

Implications:

Vigilance is required for patients with rapidly progressive or aggressive implant loosening and osteolysis post-TKA.
Multidisciplinary team guidance is essential for managing these complex cases.
Limb salvage or amputation are often necessary treatment modalities for periprosthetic osteosarcoma.