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Serum β-klotho is a potential biomarker for the progression of hepatitis B virus-related liver diseases
Xin Miao1, ChuYan Peng1, Fang Yan2
1Department of Hepatology, Chongqing University Three Gorges Hospital, Chongqing, China.
Journal of Infection in Developing Countries
|May 10, 2024
Summary
Serum beta-klotho (KLB) levels increase with Hepatitis B virus (HBV) liver disease severity. KLB shows diagnostic potential for liver cancer (HCC), outperforming alpha-fetoprotein (AFP).
Area of Science:
- Hepatology
- Biomarker Discovery
- Viral Hepatitis Research
Background:
- Hepatitis B virus (HBV) infection poses a global health challenge, leading to severe liver conditions.
- Identifying reliable biomarkers is crucial for managing HBV-related liver diseases.
Purpose of the Study:
- To evaluate serum beta-klotho (KLB) as a potential biomarker in HBV-related liver diseases.
- To assess the diagnostic value of KLB in distinguishing disease stages and hepatocellular carcinoma (HCC).
Main Methods:
- Serum KLB levels were measured using ELISA in healthy individuals and patients with chronic hepatitis B (CHB), HBV-related cirrhosis, and HBV-related HCC.
- Statistical analyses compared KLB levels across groups and correlated them with clinical parameters.
Main Results:
- Serum KLB levels increased progressively from healthy controls to CHB, cirrhosis, and HCC groups.
- KLB levels positively correlated with markers of liver damage and disease severity, and negatively with factors like platelet count and albumin.
- Serum KLB demonstrated superior diagnostic sensitivity for HCC compared to alpha-fetoprotein (AFP), with combined KLB and AFP showing enhanced diagnostic accuracy.
Conclusions:
- Serum KLB is associated with the progression of HBV-related liver diseases.
- KLB serves as a valuable diagnostic biomarker for HCC and can aid in monitoring disease progression.
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