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Hepatitis B Virus Neutralization with DNA Origami Nanoshells
Elena M Willner1, Fenna Kolbe2, Frank Momburg3
1Department of Biosciences, School of Natural Sciences and Munich Institute of Biomedical Engineering, Technical University of Munich, Boltzmannstraße 11, 85748 Garching, Germany.
ACS Applied Materials & Interfaces
|May 10, 2024
Summary
DNA origami nanoshells trap and neutralize hepatitis B virus (HBV) effectively. This novel antiviral strategy enhances antibody potency by 100-fold, offering a promising new approach for combating viral infections.
Area of Science:
- Nanotechnology
- Virology
- Biochemistry
Background:
- Hepatitis B virus (HBV) poses a significant global health challenge.
- Current antiviral therapies have limitations in efficacy and resistance.
- Developing novel strategies for virus neutralization is crucial.
Purpose of the Study:
- To demonstrate the use of DNA origami nanoshells for virus trapping.
- To evaluate the neutralization efficiency of these nanoshells against HBV.
- To investigate the mechanisms behind enhanced antiviral activity.
Main Methods:
- Fabrication of virus-trapping nanoshells using DNA origami.
- Modification of nanoshells with synthetic monoclonal antibodies targeting the HBV envelope.
- Assessment of HBV neutralization in cell culture models.
Main Results:
- DNA origami nanoshells efficiently trapped and neutralized HBV in cell culture.
- Antibody-modified nanoshells exhibited approximately 100-fold increased neutralization potency compared to free antibodies.
- Nanoshells acted as a physical barrier and enhanced virus binding through avidity.
Conclusions:
- DNA origami-based nanoshells represent a potent antiviral platform.
- This system significantly enhances the effectiveness of antibodies for virus neutralization.
- The study highlights the potential for rationally designing antivirals using DNA nanotechnology.
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