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Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

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Hepatitis B Virus Neutralization with DNA Origami Nanoshells.

Elena M Willner¹, Fenna Kolbe², Frank Momburg³

¹Department of Biosciences, School of Natural Sciences and Munich Institute of Biomedical Engineering, Technical University of Munich, Boltzmannstraße 11, 85748 Garching, Germany.

ACS Applied Materials & Interfaces

|May 10, 2024

Summary

DNA origami nanoshells trap and neutralize hepatitis B virus (HBV) effectively. This novel antiviral strategy enhances antibody potency by 100-fold, offering a promising new approach for combating viral infections.

Keywords:

DNA origami antivirals hepatitis B virus in vitro neutralization viral blocking

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Area of Science:

Nanotechnology
Virology
Biochemistry

Background:

Hepatitis B virus (HBV) poses a significant global health challenge.
Current antiviral therapies have limitations in efficacy and resistance.
Developing novel strategies for virus neutralization is crucial.

Purpose of the Study:

To demonstrate the use of DNA origami nanoshells for virus trapping.
To evaluate the neutralization efficiency of these nanoshells against HBV.
To investigate the mechanisms behind enhanced antiviral activity.

Main Methods:

Fabrication of virus-trapping nanoshells using DNA origami.
Modification of nanoshells with synthetic monoclonal antibodies targeting the HBV envelope.
Assessment of HBV neutralization in cell culture models.

Main Results:

DNA origami nanoshells efficiently trapped and neutralized HBV in cell culture.
Antibody-modified nanoshells exhibited approximately 100-fold increased neutralization potency compared to free antibodies.
Nanoshells acted as a physical barrier and enhanced virus binding through avidity.

Conclusions:

DNA origami-based nanoshells represent a potent antiviral platform.
This system significantly enhances the effectiveness of antibodies for virus neutralization.
The study highlights the potential for rationally designing antivirals using DNA nanotechnology.