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Related Experiment Video

Updated: Jun 26, 2025

Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations
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ForCEPSS-A framework for cardiac electrophysiology simulations standardization.

Matthias A F Gsell1, Aurel Neic2, Martin J Bishop3

  • 1Gottfried Schatz Research Center, Division of Medical Physics and Biophysics, Medical University of Graz, Graz, Austria.

Computer Methods and Programs in Biomedicine
|May 10, 2024
PubMed
Summary

ForCEPSS standardizes cardiac electrophysiology (CEP) simulations, offering an automated workflow for efficient, robust, and reproducible research. This framework enhances the reliability of in silico CEP experiments.

Keywords:
Cardiac electrophysiologyStandardized workflowopenCARP

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Area of Science:

  • Computational biology
  • Biomedical engineering
  • Cardiovascular research

Background:

  • Cardiac electrophysiology (CEP) simulations are vital research tools.
  • Current CEP workflows lack standardization, hindering efficiency and reproducibility.
  • Existing methods often involve complex, variable, and re-implemented processing stages.

Purpose of the Study:

  • To propose ForCEPSS, a software framework for standardizing CEP simulation studies.
  • To enhance the efficiency, robustness, and reproducibility of computational CEP research.
  • To provide a flexible and automated workflow for CEP simulation.

Main Methods:

  • Developed a standardized workflow building on openCARP and carputils.
  • Implemented key processing stages: phenotype initialization, tissue calibration, functional initialization, and simulation execution.
  • Utilized ForCEPSS for an exemplar application in Virtual Arrhythmia Risk Prediction.

Main Results:

  • ForCEPSS enables a fully automated execution of complex CEP protocols.
  • The framework standardizes definition and initialization of action potential phenotypes.
  • Demonstrated successful application in investigating arrhythmogenic risk in cardiomyopathy patients.

Conclusions:

  • ForCEPSS provides a comprehensive, standardized, and automated CEP simulation workflow.
  • The automation accelerates studies, reduces errors, and improves reproducibility.
  • ForCEPSS promotes transparency and standardization in in silico cardiac electrophysiology research.