Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Development of the Lymphatic System

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Setup and Positioning in Immediate Lymphatic Reconstruction.

Plastic and reconstructive surgery. Global open·2026

Same author

Navigating the landscape of novel meshes: comprehensive review of physicomechanical categorization of mesh for hernia repair.

Hernia : the journal of hernias and abdominal wall surgery·2026

Same author

National Analysis of Insurance Coverage for Gender-Affirming Surgery in the United States.

LGBT health·2026

Same author

Nationwide Spatial Analysis of Orofacial Cleft Prevalence in Ecuador: Geographic Variations and Clustering Across the Andean Region.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2026

Same author

Systemic Lupus Erythematosus in Complications of Mastectomies With or Without Reconstruction.

The Journal of surgical research·2026

Same author

Predictors of the Integrated Plastic Surgery Applicant Success Using the Texas STAR Database.

Journal of surgical education·2026

Search research articles

Related Experiment Video

Updated: Jul 6, 2026

Murine Superficial Lymph Node Surgery

Murine Superficial Lymph Node Surgery

Published on: May 21, 2012

Immediate lymphatic reconstruction: Lessons learned over eight years.

Rosie Friedman¹, Mohamed A Ismail Aly¹, James E Fanning¹

¹Division of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS

|May 10, 2024

Summary

Immediate lymphatic reconstruction (ILR) reduces secondary lymphedema risk after breast cancer surgery. Our center refined ILR techniques, enhancing success and promoting wider adoption for breast cancer-related lymphedema prevention.

Keywords:

Breast Breast cancer-related lymphedema Immediate lymphatic reconstruction Lymphatic surgery Lymphedema

More Related Videos

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

Published on: November 2, 2019

A Murine Tail Lymphedema Model

A Murine Tail Lymphedema Model

Published on: February 10, 2021

Related Experiment Videos

Last Updated: Jul 6, 2026

Murine Superficial Lymph Node Surgery

Murine Superficial Lymph Node Surgery

Published on: May 21, 2012

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

Published on: November 2, 2019

A Murine Tail Lymphedema Model

A Murine Tail Lymphedema Model

Published on: February 10, 2021

Area of Science:

Surgical Oncology
Lymphedema Management
Microsurgery

Background:

Secondary lymphedema is a common complication following breast cancer treatment.
Immediate lymphatic reconstruction (ILR) shows promise in reducing lymphedema risk.
Evidence supporting the efficacy of ILR is growing.

Purpose of the Study:

To share institutional modifications and advancements in ILR techniques for breast cancer-related lymphedema (BCRL) risk reduction.
To facilitate wider adoption and discussion of ILR within the surgical community.
To improve operative success rates for ILR procedures.

Main Methods:

Utilized indocyanine green (ICG) and fluorescein isothiocyanate for lymphatic visualization and anatomical variation assessment.
Applied the lymphosome concept for optimized arm injection sites.
Incorporated intraoperative tools for enhanced axillary visualization and vein grafts to prevent complications.
Standardized data collection for future outcome studies.

Main Results:

Developed and refined several modifications to enhance ILR operative success.
Successfully applied advanced imaging and surgical techniques for BCRL risk reduction.
Established a centralized ILR service in New England.

Conclusions:

Institutional modifications have improved the success of ILR for BCRL risk reduction.
Sharing these advancements can foster broader adoption and further development of ILR.
ILR represents a valuable approach for preventing secondary lymphedema in breast cancer patients.