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Updated: Jun 26, 2025

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RanGAP1 maintains chromosome stability in limb bud mesenchymal cells during bone development

Minjun Huang1, Bochong Chen2, Xiaoli Chen2

  • 1Department of Spine Surgery, The Tenth Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Dongguan 523059, China; Department of Orthopaedics, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Orthopedic Hospital of Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.

Cellular Signalling
|May 10, 2024
PubMed
Summary

RanGAP1 is essential for bone development by maintaining chromosome stability in mesenchymal cells. Its loss causes embryonic lethality and skeletal defects due to chromosome missegregation and altered signaling.

Keywords:
Bone developmentChromosomal instabilityMesenchymal stem cellsRanGAP1

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