Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
Development of Blood Vessels01:07

Development of Blood Vessels

577
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
577
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

5.4K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
5.4K
Structure of Blood Vessels01:15

Structure of Blood Vessels

4.4K
Blood is circulated throughout the human body through a network of blood vessels called the circulatory system. This system includes arteries that transport blood from the heart to various body parts. These arterial pathways divide into smaller vessels until they reach the arterioles, which further split into capillaries. It is within these minuscule capillaries that the exchange of nutrients and waste products takes place. After this exchange, the blood is collected by venules, which fuse to...
4.4K
Bone Remodeling01:40

Bone Remodeling

38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

4.0K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasminogen Activator Inhibitor-1 is Internalized by Endothelial Cells via A Pinocytosis-Like Mechanism and Evades Degradation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

RIG-I RNA agonist activates immunostimulatory macrophages to enhance checkpoint immunotherapy for glioblastoma.

bioRxiv : the preprint server for biology·2026
Same author

Identification of a thermogenic target in the dorsal raphe nucleus for weight management in mice.

Nature communications·2026
Same author

Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction.

Nature communications·2025
Same author

Endothelial Rho kinase controls blood vessel integrity and angiogenesis.

Cardiovascular research·2025
Same author

Resolving the mysteries of brain clearance and immune surveillance.

Neuron·2025
Same journal

Building a resilient ovarian reserve: Early soma-oocyte interactions.

Current topics in developmental biology·2026
Same journal

Role of macrophages in testis function.

Current topics in developmental biology·2026
Same journal

Role of retinoic acid in meiosis.

Current topics in developmental biology·2026
Same journal

Impact of cancer immunotherapies on oocyte health and ovarian function.

Current topics in developmental biology·2026
Same journal

The ovarian stroma as a key regulator of follicular development and gamete quality across the reproductive lifespan.

Current topics in developmental biology·2026
Same journal

Intercellular cyclic nucleotide dynamics mediate oocyte meiosis in mammalian preovulatory follicles.

Current topics in developmental biology·2026
See all related articles

Related Experiment Video

Updated: Jun 26, 2025

A Novel Mammary Fat Pad Transplantation Technique to Visualize the Vessel Generation of Vascular Endothelial Stem Cells
12:41

A Novel Mammary Fat Pad Transplantation Technique to Visualize the Vessel Generation of Vascular Endothelial Stem Cells

Published on: August 3, 2017

9.2K

Vascular development, remodeling and maturation.

Jessica Furtado1, Anne Eichmann2

  • 1Department of Molecular and Cellular Physiology, Yale University School of Medicine, New Haven, CT, United States; Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, United States.

Current Topics in Developmental Biology
|May 10, 2024
PubMed
Summary
This summary is machine-generated.

Vascular system development involves three key stages, from embryonic differentiation to mature, organ-specific blood vessels. Understanding endothelial cell heterogeneity offers new therapeutic avenues for vascular diseases.

Keywords:
Arterio-venous differentiationEndothelial heterogeneitySprouting angiogenesisVascular developmentVascular formationVascular remodelingVessel maturationVessel stabilization

More Related Videos

Micropatterning and Assembly of 3D Microvessels
13:05

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

11.8K
The Arteriovenous AV Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering
08:53

The Arteriovenous AV Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

Published on: November 2, 2016

12.5K

Related Experiment Videos

Last Updated: Jun 26, 2025

A Novel Mammary Fat Pad Transplantation Technique to Visualize the Vessel Generation of Vascular Endothelial Stem Cells
12:41

A Novel Mammary Fat Pad Transplantation Technique to Visualize the Vessel Generation of Vascular Endothelial Stem Cells

Published on: August 3, 2017

9.2K
Micropatterning and Assembly of 3D Microvessels
13:05

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

11.8K
The Arteriovenous AV Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering
08:53

The Arteriovenous AV Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

Published on: November 2, 2016

12.5K

Area of Science:

  • Vascular biology
  • Developmental biology
  • Endothelial cell biology

Background:

  • Vascular system development is vital for organ health.
  • Vascular dysfunction causes significant human morbidity and mortality.

Purpose of the Study:

  • To discuss the three successive processes governing vascular system development.
  • To highlight the heterogeneity of endothelial cells and its implications.

Main Methods:

  • Review of embryonic vascular development.
  • Analysis of vascular remodeling into arteries and veins.
  • Examination of endothelial cell maturation and barrier function.

Main Results:

  • Vascular development proceeds through differentiation, remodeling, and maturation.
  • Endothelial cells exhibit significant heterogeneity in gene expression and function.
  • Acquisition of an organ-specific semi-permeable barrier is crucial for organ physiology.

Conclusions:

  • Understanding vascular development advances knowledge in vascular biology.
  • Endothelial cell heterogeneity presents therapeutic potential for vascular diseases.