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High molecular weight alkaline phosphatase: a clinical study.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|November 2, 1979
Summary
High molecular weight alkaline phosphatase is a sensitive and specific marker for detecting liver disease, especially obstructive types. This enzyme test shows promise for the early detection of liver metastases, outperforming other liver function tests.
Area of Science:
- Biochemistry
- Clinical Chemistry
- Hepatology
Background:
- Alkaline phosphatase (ALP) is an enzyme found in various tissues, with elevated levels often indicating liver or bone disease.
- Assessing high molecular weight (HMW) ALP isoenzymes may offer improved diagnostic specificity for liver conditions.
Purpose of the Study:
- To evaluate the diagnostic utility of HMW alkaline phosphatase activity in patients with liver disease.
- To compare the efficacy of HMW alkaline phosphatase with other liver function tests (LFTs) for diagnosing liver conditions and metastases.
Main Methods:
- Serum samples from 72 patients with liver disease, 14 with bone disease, and 8 healthy volunteers were analyzed.
- Measurements of HMW alkaline phosphatase activity were compared with standard hepatic function indices.
Main Results:
- HMW alkaline phosphatase activity demonstrated high sensitivity and specificity for detecting liver disease, particularly obstructive cholestasis.
- The HMW ALP test was superior to other LFTs in differentiating liver metastases from other hepatobiliary disorders.
Conclusions:
- HMW alkaline phosphatase is a valuable biomarker for diagnosing liver disease and identifying obstructive patterns.
- This enzyme assay shows significant potential for the early detection of liver metastases, aiding in clinical management.