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Levels of sCD163 in women rheumatoid arthritis: Relationship with cardiovascular risk markers
Oscar Zaragoza-García1, Olivia Briceño2, José Rafael Villafan-Bernal3
1Laboratory of Multidisciplinary Research and Biomedical Innovation, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, Mexico.
Insights
Soluble CD163 (sCD163) levels indicate higher cardiovascular risk and disease activity in rheumatoid arthritis (RA) patients. This marker may serve as a predictor for cardiovascular complications in RA.
Area of Science:
- Rheumatology
- Cardiology
- Biomarkers
Background:
- Soluble scavenger receptor differentiation antigen 163 (sCD163) is a marker of monocyte/macrophage activation.
- Elevated sCD163 levels are linked to cardiovascular mortality in the general population.
Purpose of the Study:
- To investigate the association between serum sCD163 levels and cardiovascular risk indicators in rheumatoid arthritis (RA).
- To evaluate sCD163 as a potential biomarker for cardiovascular risk and disease activity in RA patients.
Main Methods:
- Cross-sectional study involving 80 women with RA.
- Cardiovascular risk assessed via lipid profile, metabolic syndrome, and QRISK3 calculator.
- RA disease activity measured by DAS28-ESR; serum sCD163 quantified using ELISA.
- Logistic regression and ROC curve analysis employed to determine associations and predictive values.
Main Results:
- Higher sCD163 levels correlated significantly with adverse lipid ratios, atherogenic index, cardiometabolic index (CMI), and high RA disease activity (DAS28-ESR).
- Multivariate analysis revealed sCD163 levels (≥1107.3ng/mL) were independently associated with high CHR, CMI, unfavorable cholesterol ratios, and high DAS28-ESR.
- Serum sCD163 demonstrated predictive value for high CHR, unfavorable cholesterol ratios, and high DAS28-ESR.
Conclusions:
- Serum sCD163 levels can serve as a surrogate marker for cardiovascular risk in RA patients.
- sCD163 may also reflect clinical disease activity in rheumatoid arthritis.
Aim:
The soluble scavenger receptor differentiation antigen 163 (sCD163), a monocyte/macrophage activation marker, is related to cardiovascular mortality in the general population. This study aimed to evaluate their relationship between serum levels of sCD163 with cardiovascular risk indicators in rheumatoid arthritis (RA).
Methods:
A cross-sectional study was performed on 80 women diagnosed with RA. The cardiovascular risks were determined using the lipid profile, metabolic syndrome, and QRISK3 calculator. For the assessment of RA activity, we evaluated the DAS28 with erythrocyte sedimentation rate (DAS28-ESR). The serum levels of sCD163 were determined by the ELISA method. Logistic regression models and receiver operating characteristics (ROC) curve were used to assess the association and predictive value of sCD163 with cardiovascular risk in RA patients.
Results:
Levels of sCD163 were significantly higher in RA patients with high sensitivity protein C-reactive to HDL-c ratio (CHR)≥0.121 (p=0.003), total cholesterol/HDL-c ratio>7% (p=0.004), LDL-c/HDL-c ratio>3% (p=0.035), atherogenic index of plasma>0.21 (p=0.004), cardiometabolic index (CMI)≥1.70 (p=0.005), and high DAS28-ESR (p=0.004). In multivariate analysis, levels of sCD163≥1107.3ng/mL were associated with CHR≥0.121 (OR=3.43, p=0.020), CMI≥1.70 (OR=4.25, p=0.005), total cholesterol/HDL-c ratio>7% (OR=6.63, p=0.044), as well as with DAS28-ESR>3.2 (OR=8.10, p=0.008). Moreover, levels of sCD163 predicted CHR≥0.121 (AUC=0.701), cholesterol total/HDL ratio>7% (AUC=0.764), and DAS28-ESR>3.2 (AUC=0.720).
Conclusion:
Serum levels of sCD163 could be considered a surrogate of cardiovascular risk and clinical activity in RA.
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