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Related Concept Videos

  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Correlations Of Expression Levels Of Lung Cancer Marker Gene Eno2 And Genes Of Carcinogenesis And Apoptosis In The Hypothalamus Of Mice With Depression-like Behavior.
  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Correlations Of Expression Levels Of Lung Cancer Marker Gene Eno2 And Genes Of Carcinogenesis And Apoptosis In The Hypothalamus Of Mice With Depression-like Behavior.

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    Correlations of Expression Levels of Lung Cancer Marker Gene Eno2 and Genes of Carcinogenesis and Apoptosis in the Hypothalamus of Mice with Depression-Like Behavior.

    A G Galyamina1, I L Kovalenko2, D A Smagin2

    • 1Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia. galyamina@bionet.nsc.ru.

    Bulletin of Experimental Biology and Medicine
    |May 10, 2024

    View abstract on PubMed

    Summary
    This summary is machine-generated.

    Chronic social stress in mice heightened lung metastasis and altered gene expression in the hypothalamus, impacting lung cancer pathways. Neuron-specific enolase (Eno2) gene expression in the hypothalamus correlated with cancer-related genes.

    Keywords:
    Eno2Warburg effectapoptosiscarcinogenesischronic social stress

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    Area of Science:

    • Neuroscience
    • Oncology
    • Psychiatry

    Background:

    • Chronic social stress is linked to various health issues.
    • Depression-like states can influence physiological processes.
    • The hypothalamus plays a role in stress response and gene regulation.

    Purpose of the Study:

    • To investigate the impact of chronic social stress on lung metastasis and gene expression in the hypothalamus.
    • To identify specific genes in the hypothalamus related to lung cancer pathogenesis and apoptosis.
    • To explore the correlation between depression-like behavior, lung metastasis, and hypothalamic gene expression.

    Main Methods:

    • Induction of chronic social stress in mice to create a depression-like state.
    • Assessment of lung metastasis.
    • Analysis of gene expression in the hypothalamus, focusing on carcinogenesis- and apoptosis-related genes.
    • Specific analysis of genes encoding major clinical markers of lung cancer.

    Main Results:

    • Chronic social stress during depression-like state development enhanced lung metastasis.
    • Hypothalamic gene expression was significantly modified, including genes linked to lung cancer.
    • Increased expression of the Eno2 gene (neuron-specific enolase), a human lung cancer marker, was observed in the hypothalamus.
    • Eno2 expression correlated with other carcinogenesis- and apoptosis-related genes.

    Conclusions:

    • Chronic social stress can exacerbate lung metastasis and alter hypothalamic gene expression relevant to lung cancer.
    • The hypothalamus, specifically Eno2 gene expression, may serve as a potential indicator linking social stress, depression, and lung cancer progression.
    • These findings highlight a fundamental connection requiring further investigation into the neuro-oncological implications of stress and depression.