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Related Concept Videos

  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. A Multicenter International Retrospective Investigation Assessing The Prognostic Role Of Inflammation-based Scores (neutrophil-to-lymphocyte, Lymphocyte-to-monocyte, And Platelet-to-lymphocyte Ratios) In Patients With Intermediate-stage Hepatocellular Carcinoma (hcc) Undergoing Chemoembolizations Of The Liver.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. A Multicenter International Retrospective Investigation Assessing The Prognostic Role Of Inflammation-based Scores (neutrophil-to-lymphocyte, Lymphocyte-to-monocyte, And Platelet-to-lymphocyte Ratios) In Patients With Intermediate-stage Hepatocellular Carcinoma (hcc) Undergoing Chemoembolizations Of The Liver.

Related Experiment Video

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
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Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

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A Multicenter International Retrospective Investigation Assessing the Prognostic Role of Inflammation-Based Scores (Neutrophil-to-Lymphocyte, Lymphocyte-to-Monocyte, and Platelet-to-Lymphocyte Ratios) in Patients with Intermediate-Stage Hepatocellular Carcinoma (HCC) Undergoing Chemoembolizations of the Liver.

Roberto Minici1, Massimo Venturini2, Giuseppe Guzzardi3

  • 1Radiology Unit, University Hospital Dulbecco, 88100 Catanzaro, Italy.

Cancers
|May 11, 2024

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
drug-eluting beads (DEB)drug-eluting microspheres (DEM)hepatocellular carcinoma (HCC)inflammation-based scores

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Inflammation-based scores like the Lymphocyte-to-Monocyte Ratio (LMR) and Neutrophil-to-Lymphocyte Ratio (NLR) can predict treatment response in intermediate-stage hepatocellular carcinoma (HCC) patients undergoing transcatheter arterial chemoembolization (TACE). Early identification of TACE refractoriness is key for personalized therapy.

Area of Science:

  • Oncology
  • Hepatology
  • Inflammation Biomarkers

Background:

  • Inflammation-based scores (NLR, LMR, PLR) show prognostic potential in cancers.
  • Predictive role of these scores in intermediate-stage HCC patients undergoing TACE needs further investigation.
  • Early recognition of TACE refractoriness can guide tailored therapeutic interventions.

Purpose of the Study:

  • To investigate the predictive role of inflammation-based scores in intermediate-stage HCC patients undergoing TACE.
  • To assess the association between preoperative NLR, LMR, and PLR with treatment outcomes.
  • To identify potential biomarkers for predicting TACE refractoriness.

Main Methods:

  • Multicenter international retrospective study (2018-2024).
  • Included patients with intermediate-stage HCC undergoing TACE.
lymphocyte-to-monocyte ratio (LMR)
neutrophil-to-lymphocyte ratio (NLR)
platelet-to-lymphocyte ratio (PLR)
prognostic marker
transcatheter arterial chemoembolization (TACE)
tumor microenvironment
  • Assessed preoperative inflammation-based scores (NLR, LMR, PLR) to predict treatment outcomes.

    • Main Results:

    • Preoperative LMR demonstrated the largest AUC for predicting 6-month PFS.
    • High LMR (≥2.24) and low NLR (<4.72) correlated with improved objective response rates and 6-month PFS.
    • Lymphocyte count was a strong predictor of treatment response in logistic regression analyses (p < 0.001).

    Conclusions:

    • Inflammation-based scores, particularly LMR and NLR, have prognostic value for predicting treatment response and short-term outcomes in intermediate-stage HCC patients undergoing TACE.
    • Further research is needed to validate these scores for clinical applicability.
    • Investigating the impact of these scores on long-term survival and therapeutic decision-making is crucial.