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  11. Temporal Muscle Thickness Compared To Functional Scales As A Prognostic Parameter In Patients With Brain Metastases

Temporal Muscle Thickness Compared to Functional Scales as a Prognostic Parameter in Patients with Brain Metastases

Julia Klingenschmid1, Aleksandrs Krigers1, Daniel Pinggera1

  • 1Department of Neurosurgery, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.

Cancers
|May 11, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Clinical Frailty Scale (CFS) effectively predicts overall survival in adult brain metastasis patients. Temporal muscle thickness (TMT) showed no prognostic value, unlike established scales like CFS and Karnofsky Performance Status (KPS).

Area of Science:

  • Neurosurgery
  • Oncology
  • Radiology

Background:

  • Intracranial metastases are the most common malignant brain tumors in adults.
  • Karnofsky Performance Status (KPS) and Clinical Frailty Scale (CFS) are established prognostic indicators for overall survival (OS).
  • Temporal muscle thickness (TMT) is a novel parameter proposed for estimating prognosis in these patients.

Purpose of the Study:

  • To evaluate the prognostic value of TMT in patients with resected brain metastases.
  • To compare the prognostic utility of TMT against established clinical scales (KPS and CFS).

Main Methods:

  • Retrospective analysis of 199 adult patients undergoing resection of 1-3 brain metastases.
  • Measurement of TMT from preoperative MRI scans using a standardized protocol.
Keywords:
brain metastasesfrailtyneurosurgeryprognosis

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  • Correlation analysis of TMT, CFS, KPS, and overall survival (OS).

    • Main Results:

    • Mean TMT was 7.5 mm; mean OS was 31.3 months.
    • TMT did not significantly correlate with OS, KPS, or CFS.
    • Both CFS and KPS significantly correlated with OS (p < 0.001), with CFS demonstrating superior prognostic value.

    Conclusions:

    • TMT is not a significant prognostic factor for overall survival or patient performance in brain metastasis.
    • Clinical scales, particularly CFS, remain valuable tools for estimating OS in patients with brain metastases.
    • CFS is recommended over KPS for superior prognostic accuracy in this patient population.
    temporal muscle thickness