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A Review of the Paradigmatic Role of Adipose Tissue in Renal Cancer: Fat Measurement and Tumor Behavior Features
Eliodoro Faiella1,2, Elva Vergantino1,2, Federica Vaccarino1,2
1Operative Reasearch Unit of Radiology and Interventional Radiology, Fondazione Policlinico Universitario Campus Bio-Medico di Roma, Via Alvaro del Portillo 200, 00128 Rome, Italy.
Cancers
|May 11, 2024
Summary
Obesity
Area of Science:
- Oncology
- Metabolism
- Epidemiology
Background:
- Rising incidence of renal-cell carcinoma (RCC) noted.
- Obesity is a suspected risk factor for RCC.
- The impact of obesity on RCC prognosis is not well understood.
Purpose of the Study:
- To systematically review the effects of various adipose tissue measurements on renal-cell carcinoma (RCC) behavior and prognosis.
- To clarify the association between obesity metrics and RCC outcomes.
Main Methods:
- Systematic literature search of MEDLINE database.
- Inclusion of 20 studies examining visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), perirenal adipose tissue (PRAT), and Mayo adhesive probability (MAP) score.
- Analysis of associations between fat measurements and RCC progression and mortality.
Main Results:
- Conflicting findings reported on the association between adipose tissue measurements and RCC outcomes.
- Some studies indicated a protective effect of visceral adipose tissue (VAT) against RCC progression and mortality.
- Contradictory results observed across different fat metrics and RCC subtypes.
Conclusions:
- Methodological limitations (e.g., retrospective designs, small sample sizes) hinder standardization and generalizability.
- Further research is required to elucidate the complex associations between adiposity and RCC.
- Standardized adiposity assessment in RCC patients is needed to guide clinical practice and treatment decisions.
