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Survivin as a Therapeutic Target for the Treatment of Human Cancer

Qiang Wang1, Mark I Greene2

  • 1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Cancers
|May 11, 2024
PubMed

Insights

Survivin, a protein regulating cell death and mitosis, is overexpressed in cancers, driving tumor growth and drug resistance. Targeting survivin offers a promising strategy for developing novel cancer therapeutics.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Cancer Research

Background:

  • Survivin, an inhibitor of apoptosis (IAP) protein, regulates apoptosis and mitotic progression.
  • It functions as a component of the chromosome passenger complex.
  • Emerging roles in mitochondrial function and autophagy are also proposed.

Purpose of the Study:

  • To review the multifaceted roles of survivin in cancer.
  • To discuss survivin's involvement in malignant transformation and drug resistance.
  • To summarize therapeutic strategies targeting survivin for cancer treatment.

Main Methods:

  • Literature review of survivin's functions and therapeutic targeting.
  • Analysis of survivin's role in apoptosis, mitosis, and cancer progression.
  • Evaluation of survivin-targeted drug development efforts.

Main Results:

  • Survivin overexpression is common in human cancers.
  • It correlates with chemotherapy resistance, recurrence, and poor patient survival.
  • Survivin's diverse functions contribute to malignant transformation.

Conclusions:

  • Survivin is a critical mediator of cancer development and progression.
  • Targeting survivin presents a viable therapeutic avenue for various cancers.
  • Further research into survivin-targeted therapies is warranted.
Keywords:
apoptosiscancermitosissurvivin

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