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Related Concept Videos

Tumor Progression02:07

Tumor Progression

6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. The Relationship Between Tumor Budding And Tumor Deposits In Patients With Stage Iii Colorectal Carcinoma.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. The Relationship Between Tumor Budding And Tumor Deposits In Patients With Stage Iii Colorectal Carcinoma.

Related Experiment Video

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

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The Relationship between Tumor Budding and Tumor Deposits in Patients with Stage III Colorectal Carcinoma.

Zdenko Bilić1, Mario Zovak1,2,3, Goran Glavčić1

  • 1Department of Surgery, Sestre Milosrdnice University Hospital Center, 10 000 Zagreb, Croatia.

Journal of Clinical Medicine
|May 11, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Tumor deposits (TDs) are more common in patients with higher tumor budding (TB) grades in stage III colorectal cancer. Both higher TB grade and increased TDs significantly correlate with shorter survival, highlighting TB

Keywords:
colorectal carcinomaepithelial-mesenchymal transitiontumor buddingtumor deposits

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Area of Science:

  • Oncology
  • Pathology
  • Surgical Oncology

Background:

  • Emerging morphological features in colorectal cancer (CRC) are recognized as critical prognostic indicators.
  • This study investigates the interrelationship between tumor budding (TB) and tumor deposits (TDs) in stage III CRC.

Purpose of the Study:

  • To determine the association between tumor deposits (TDs) and tumor budding (TB) in stage III colorectal cancer.
  • To evaluate the prognostic significance of TB and TDs on patient survival.

Main Methods:

  • Retrospective cohort study of 90 patients with stage III CRC undergoing radical surgical resection.
  • Histopathological review of H&E-stained slides to assess TB grade and presence of TDs.
  • Comparison of TB and TDs with clinical and histological features and patient survival.

Main Results:

  • A high prevalence of TB (94.4%) was observed in the cohort.
  • The presence of TDs was significantly associated with a higher number of TB (OR 16.3) and higher TB grade (OR 11.04).
  • Higher TB grade (HR 2.28) and increasing TDs (HR 1.52) were significantly linked to shorter overall survival.

Conclusions:

  • Tumor deposits are more frequent in stage III CRC patients with higher tumor budding grades.
  • Both advanced tumor budding and a greater number of tumor deposits are significant predictors of reduced overall survival.
  • These findings underscore the importance of tumor budding as an adverse prognostic factor in colorectal cancer.