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The Effect of Open and Closed Oocyte Vitrification Systems on Embryo Development: A Systematic Review and Network
Konstantinos Pantos1, Evangelos Maziotis1,2, Anna Trypidi2
1Centre for Human Reproduction, Genesis Athens Clinic, Papanikoli, 15232 Athens, Greece.
Journal of Clinical Medicine
|May 11, 2024
Summary
Closed vitrification systems show better outcomes for oocyte cryopreservation compared to open systems. Closed systems maintain oocyte competence, leading to higher blastocyst formation rates, crucial for successful fertility treatments.
Area of Science:
- Reproductive Biology
- Cryobiology
- In Vitro Fertilization
Background:
- Oocyte cryopreservation utilizes open and closed vitrification systems.
- Limited comparative data exists on their impact on oocyte competence and clinical outcomes.
Purpose of the Study:
- To compare the effects of open versus closed vitrification systems on laboratory and clinical outcomes.
- To analyze the impact of cooling and warming rates in oocyte vitrification.
Main Methods:
- Systematic literature search of PubMed/MEDLINE and Cochrane Central Library (up to January 2023).
- Network meta-analysis comparing vitrification systems against fresh oocytes.
- Inclusion of 23 studies.
Main Results:
- Both vitrification systems showed lower fertilization rates than fresh oocytes.
- No significant difference in survival rates between open and closed systems.
- Open systems had lower cleavage and blastocyst rates compared to fresh controls; closed systems did not.
Conclusions:
- Closed vitrification systems appear to have a less detrimental effect on oocyte competence.
- This is evidenced by superior blastocyst formation rates compared to open systems.
- Standardization of closed systems could optimize oocyte vitrification practices.
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