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The acute phase response in acute anterior uveitis
Transactions of the Ophthalmological Societies of the United Kingdom
|January 1, 1985
Summary
Serum amyloid A (SAA) levels in acute anterior uveitis patients indicate recurrence risk. Non-responders to inflammation, with normal SAA, show a higher tendency for recurrent uveitis attacks.
Area of Science:
- Ophthalmology
- Immunology
- Inflammation
Background:
- The acute phase response is a systemic reaction to inflammation involving acute phase protein synthesis.
- Serum amyloid A (SAA) is a key acute phase protein.
- Acute anterior uveitis is an inflammatory eye condition.
Purpose of the Study:
- To investigate the role of serum amyloid A (SAA) in acute anterior uveitis (AAU).
- To determine if SAA levels correlate with disease severity or recurrence in AAU patients.
Main Methods:
- Serial measurement of SAA concentrations in 57 patients with acute anterior uveitis.
- Classification of patients into SAA responders (transient elevation) and non-responders (normal levels).
- Analysis of patient demographics, uveitis severity, recurrence history, and HLA B27 status.
Main Results:
- Thirty-eight patients were responders, and 19 were non-responders; groups had similar demographics and uveitis severity.
- SAA concentration at presentation did not correlate with uveitis severity.
- Non-responders tended to have more previous uveitis attacks compared to responders.
- HLA B27 was more frequent in recurrent disease and predominantly found in responders.
Conclusions:
- SAA concentration does not predict the severity of an acute anterior uveitis attack.
- Absence of an acute phase response (normal SAA) may be linked to a higher likelihood of recurrent uveitis.
- HLA B27 positivity is associated with recurrent disease and is more common in SAA responders.