Diagnosis of Canine Tumours and the Value of Combined Detection of VEGF, P53, SF and NLRP3 for the Early Diagnosis of Canine Mammary Carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.Early diagnosis of canine mammary tumors is crucial. A combination of four biomarkers, including vascular endothelial growth factor (VEGF) and tumor protein P53 (P53), shows promise for accurate detection in dogs.
Area Of Science
- Veterinary Medicine
- Oncology
- Biomarker Discovery
Background
- Canine mammary tumors are a leading cause of death in dogs.
- Early diagnosis is critical for effective treatment and improved prognosis.
- Current diagnostic methods have limitations in early detection.
Purpose Of The Study
- To evaluate the diagnostic potential of four biomarkers for canine mammary tumors.
- To compare the expression levels of these biomarkers in healthy dogs, dogs with benign tumors, and dogs with malignant tumors.
Main Methods
- RT-qPCR and ELISA were used to measure the expression of VEGF, P53, serum ferritin (SF), and NLRP3.
- Samples were analyzed from healthy dogs, dogs with benign mammary tumors, and dogs with malignant mammary tumors.
- ROC curve analysis was performed to assess diagnostic accuracy.
Main Results
- All four biomarkers (VEGF, P53, SF, NLRP3) showed significantly higher expression in malignant mammary tumors compared to benign tumors and healthy controls.
- Expression trends were consistent in both serum and tissue samples.
- Combined testing of the four markers demonstrated superior diagnostic performance over single marker tests.
Conclusions
- The combination of VEGF, P53, SF, and NLRP3 shows significant potential for the early and accurate diagnosis of canine mammary tumors.
- These findings can aid in clinical diagnosis and the development of novel tumor detection kits for veterinary practice.
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