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Deoxycytidylate deaminase in the diagnosis of acute myocardial infarction

C Georgiades, D V Cokkinos, A Kalofoutis

    Acta Cardiologica
    |January 1, 1985
    PubMed

    Insights

    Deoxycytidylate deaminase (dCMP) shows high diagnostic accuracy for acute myocardial infarction (AMI). This enzyme

    Area of Science:

    • Biochemistry
    • Clinical Diagnostics
    • Cardiology

    Background:

    • Acute myocardial infarction (AMI) diagnosis relies on specific biomarkers.
    • Early and accurate diagnosis is crucial for effective treatment and improved patient outcomes.
    • Novel biomarkers are continuously being investigated to enhance diagnostic capabilities.

    Purpose of the Study:

    • To evaluate the diagnostic utility of deoxycytidylate deaminase (dCMP) in patients with acute myocardial infarction (AMI).
    • To compare the diagnostic performance of dCMP with established cardiac biomarkers.
    • To explore the potential of dCMP in assessing myocardial healing.

    Main Methods:

    • Assessed dCMP levels in 31 healthy controls and 32 patients with proven AMI.
    • Determined specificity and sensitivity of dCMP at different post-infarct stages.
    • Correlated peak dCMP levels with established cardiac enzymes like SGOT, LDH, CPK, and CPK-MB.

    Main Results:

    • dCMP demonstrated high specificity (93.5%) in healthy controls.
    • Peak dCMP sensitivity reached 97.5% between the 3rd and 5th post-infarct day.
    • dCMP performance was comparable to SGOT, LDH1/LDH2 ratio, total CPK, and CPK-MB, with significant correlations (p < 0.001).

    Conclusions:

    • dCMP is a valuable complementary biomarker for diagnosing AMI.
    • dCMP is unaffected by lung infarction or hemolysis, offering diagnostic advantages.
    • Its association with tissue regeneration suggests potential in monitoring myocardial healing interventions.

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