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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Factors Influencing Drug Absorption: Drug Dissolution01:27

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The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
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Theories of Dissolution: Diffusion Layer Model01:15

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Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
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Factors Influencing Drug Absorption: Physicochemical Parameters01:22

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The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
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  11. Influence Of Casting Variables On Release Kinetics Of Orally Disintegrating Film.

Influence of Casting Variables on Release Kinetics of Orally Disintegrating Film.

Jang-Ho Shin1, Jung-Ah Han2

  • 1Department of Food Service Management and Nutrition, Sangmyung University, Seoul 03016, Republic of Korea.

Foods (Basel, Switzerland)
|May 11, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Hyaluronic acid-based orally disintegrating films (ODFs) deliver vitamin C effectively. Optimal film thickness for ODFs balances vitamin C delivery with user comfort, suggesting 2-4 mm is ideal.

Area of Science:

  • Pharmaceutical Technology
  • Materials Science

Background:

  • Orally disintegrating films (ODFs) offer a novel delivery method for nutrients like vitamin C.
  • Hyaluronic acid (HA) is explored as a base material for ODFs due to its biocompatibility and film-forming properties.

Purpose of the Study:

  • To develop and characterize vitamin C-loaded ODFs using hyaluronic acid.
  • To investigate the impact of casting conditions, specifically film thickness and manufacturing method, on ODF properties and vitamin C release.

Main Methods:

  • ODFs were fabricated with varying thicknesses (2, 3, 8 mm) and casting methods (single vs. double casting).
  • Properties analyzed included water vapor permeability, tensile strength, disintegration time, and dissolution profiles.
  • Vitamin C content and release kinetics were evaluated, adhering to the Hixson-Crowell cube root law.
Keywords:
casting thicknessdissolution patternorally disintegrating filmrelease mechanism

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Main Results:

  • Increased film thickness correlated with higher water vapor permeability and tensile strength.
  • Double casting resulted in stronger ODFs with reduced disintegration compared to single casting.
  • All ODFs provided the recommended daily vitamin C intake (45 mg/day) per sheet.
  • Vitamin C release followed the Hixson-Crowell law, driven by diffusion and HA erosion, with erosion dominating in thicker films (CT8).

Conclusions:

  • Hyaluronic acid ODFs are a viable vitamin C delivery system.
  • Film thickness significantly influences physical properties and release kinetics.
  • A thickness of 2-4 mm is recommended to minimize foreign body sensation and enhance user experience.
vitamin C