Host-Microbiome Crosstalk in Chronic Wound Healing

Area of Science:

• Wound healing research
• Microbiology
• Immunology

Background:

• Chronic wounds (CW) pathogenesis involves complex biochemical, immunological, hematological, and microbiological factors.
• Biofilms significantly impact CW development and management by promoting prolonged inflammation and delayed healing.
• Wound fluid composition, including cytokines and microRNAs, further complicates the wound microenvironment.

Purpose of the Study:

• To review current progress in host-microbiome crosstalk in chronic wound healing.
• To highlight innovative strategies for enhancing host immune response against wound infections.
• To explore the potential of omics technologies and probiotics in advancing CW treatments.

Main Methods:

• Review of existing literature on chronic wound pathogenesis and host-microbiome interactions.
• Analysis of the role of biofilms and wound fluid components in delayed healing.
• Exploration of high-throughput 'omics' modalities (genomic, proteomic, etc.) for biomarker discovery.

Main Results:

• Biofilms contribute to chronic inflammation and delayed healing in chronic wounds.
• Wound fluid exhibits pro-inflammatory properties and complex molecular crosstalk.
• 'Omics' approaches offer potential for identifying biomarkers for wound healing.
• Host-microbiome interactions are crucial in the context of chronic wound infections.

Conclusions:

• Understanding host-microbiome crosstalk is key to developing effective chronic wound therapies.
• Harnessing microorganisms like probiotics presents a promising strategy for infection control.
• 'Omics' technologies and innovative immune-boosting strategies are vital for future advancements in chronic wound management.