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Updated: Jun 26, 2025

Neutrophil Extracellular Traps Generated by Low Density Neutrophils Obtained from Peritoneal Lavage Fluid Mediate Tumor Cell Growth and Attachment
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The Bifunctional Effects of Lactoferrin (LFcinB11) in Inhibiting Neural Cell Adhesive Molecule (NCAM) Polysialylation

Bo Lu1, Si-Ming Liao1, Shi-Jie Liang1

  • 1National Key Laboratory of Non-Food Biomass Energy Technology, National Engineering Research Center for Non-Food Biorefinery, Institute of Biological Science and Technology, Guangxi Academy of Sciences, 98 Daling Road, Nanning 530007, China.

International Journal of Molecular Sciences
|May 11, 2024
PubMed
Summary

Lactoferrin (LFcinB11) shows potential as a bifunctional inhibitor, blocking tumor cell migration via NCAM polysialylation and reducing neutrophil extracellular traps (NETs) release, suggesting therapeutic applications.

Keywords:
NMR spectroscopychemical shift perturbationlactoferrin (LFcinB11)migration of tumor cellsneuronal cell adhesion moleculeneutrophil extracellular traps (NETs)polysialic acidpolysialyltransferasepolysialyltransferase domain

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