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Pharmacotherapy for Keloids and Hypertrophic Scars
Teruo Murakami1, Sadayuki Shigeki2
1Laboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmaceutical Sciences, Hiroshima International University, Higashi-Hiroshima 731-2631, Japan.
International Journal of Molecular Sciences
|May 11, 2024
Summary
Pharmacotherapy for keloids (KD) and hypertrophic scars (HTS) is still evolving. Combination treatments targeting multiple pathways show more promise than single-drug therapies for improving patient quality of life.
Area of Science:
- Dermatology
- Wound Healing
- Pharmacology
Background:
- Keloids (KD) and hypertrophic scars (HTS) result from abnormal cutaneous wound healing, influenced by genetics.
- These raised, pigmented scars significantly impair patients' quality of life due to pain, itching, and cosmetic concerns.
- Current treatments for KD and HTS are under development to better satisfy patient needs.
Purpose of the Study:
- To review pharmacotherapy options for treating keloids and hypertrophic scars.
- To evaluate pharmacotherapy for preventing postsurgical recurrence of keloids.
- To explore both monotherapy and combination pharmacotherapy approaches.
Main Methods:
- Literature search using PubMed, Google Scholar, and online search engines.
- Review of pharmacotherapy administered orally, topically, and via intralesional injection.
- Consideration of pharmacotherapy combined with surgical excision and physical therapies (cryotherapy, laser, radiotherapy, silicone).
Main Results:
- Clinical effectiveness of monotherapy for KD/HTS varies among studies.
- Multimodal combination pharmacotherapy demonstrates greater efficacy than monotherapy.
- Pharmacotherapy plays a role in managing KD/HTS and preventing recurrence.
Conclusions:
- Combination pharmacotherapy targeting multiple sites is more effective for KD/HTS management.
- Further research is needed to optimize pharmacotherapy for improved patient outcomes and quality of life.
- Pharmacotherapy, often in conjunction with other modalities, is a key strategy for treating and preventing keloids and hypertrophic scars.
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