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Updated: Jun 26, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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Connective Tissue Growth Factor: Regulation, Diseases, and Drug Discovery

Meishen Ren1,2, Shanshan Yao3, Tienan Chen2

  • 1Key Laboratory of Animal Diseases and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.

International Journal of Molecular Sciences
|May 11, 2024
PubMed

Insights

This review summarizes Connective Tissue Growth Factor (CTGF) roles in disease and explores CTGF-targeting drugs. Understanding CTGF mechanisms aids novel drug discovery for various conditions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Drug Discovery

Background:

  • Connective Tissue Growth Factor (CTGF), also known as CCN2, is a key regulator in diseases like fibrosis, cancer, and neurological disorders.
  • Targeted molecule selection is critical for drug efficacy and treatment success in drug discovery.

Purpose of the Study:

  • To review CTGF structure and its regulatory roles across diverse diseases.
  • To summarize CTGF-targeting and inhibitory drugs for efficacy and application analysis.
  • To provide references for future drug discovery targeting CTGF.

Main Methods:

  • Literature review of CTGF structure and function.
  • Analysis of CTGF's role in various disease models.
  • Compilation of data on CTGF-targeting drugs and their therapeutic potential.

Main Results:

  • CTGF is implicated in the pathogenesis of multiple diseases.
  • Various drugs targeting CTGF have been developed.
  • Understanding CTGF pathways is crucial for developing effective therapies.

Conclusions:

  • CTGF is a significant therapeutic target for numerous diseases.
  • Further research into CTGF regulation and drug development is warranted.
  • This review offers insights into CTGF-based drug discovery strategies.
Keywords:
CTGF-related diseasesCTGF/CCN2drug discoveryregulation mechanismtherapeutic target

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