Related Experiment Video
Updated: May 11, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
Published on: February 21, 2018
Abstract:
The development of systems for the cloning and clonal differentiation of normal hematopoietic cells in culture made it possible to study the controls that regulate normal growth and differentiation and the changes in these controls in leukemia. Identification of the changes in normal controls that occur in leukemia reveals that the stopping of growth by inducing differentiation of malignant cells can by-pass genetic changes that produce the malignant phenotype. The induction of differentiation in leukemic cells can therefore be a useful approach to therapy.
Related Concept Videos
Lineage Commitment
Differentiation of Common Myeloid Progenitor Cells
Regulation of Hematopoietic Stem Cells
Cellular Differentiation
A zygote is a...
Production of Formed Elements
Most HSCs commit to...
Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...

