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Related Concept Videos

Cancer Vaccines01:30

Cancer Vaccines

358
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
358
Tumor Immunotherapy01:27

Tumor Immunotherapy

518
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.6K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

6.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Tumor-derived Antigenic Peptides As Potential Cancer Vaccines.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Tumor-derived Antigenic Peptides As Potential Cancer Vaccines.

Related Experiment Video

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo
07:33

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Published on: September 28, 2022

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Tumor-Derived Antigenic Peptides as Potential Cancer Vaccines.

Stanislav Sotirov1, Ivan Dimitrov1

  • 1Drug Design and Bioinformatics Lab, Faculty of Pharmacy, Medical University of Sofia, 2, Dunav Str., 1000 Sofia, Bulgaria.

International Journal of Molecular Sciences
|May 11, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Peptide cancer vaccines show promise in preventing and eradicating tumors by targeting tumor-specific antigens (TSAs) and tumor-associated antigens (TAAs). Ongoing research and clinical trials explore their efficacy and novel delivery methods for improved cancer treatment.

Keywords:
antigenbioinformaticscancerimmunogenicity

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Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
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Related Experiment Videos

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo
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Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
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Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

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Area of Science:

  • Immunology
  • Oncology
  • Vaccinology

Background:

  • Peptide antigens from tumors, classified as tumor-associated antigens (TAAs) or tumor-specific antigens (TSAs), can trigger protective immune responses.
  • Subunit cancer vaccines utilizing these antigens have demonstrated potential in cancer prevention and eradication.
  • Peptide-based cancer vaccines are increasingly utilized as a therapeutic strategy, often in conjunction with other cancer treatments.

Purpose of the Study:

  • To provide an overview of recent advancements in peptide-based cancer vaccines.
  • To summarize computational methods for tumor neoantigen prediction.
  • To review ongoing clinical trials and human vaccination experiments.

Main Methods:

  • Review of existing literature on peptide-based cancer vaccines.
vaccine
  • Summary of computational approaches for neoantigen identification.
  • Analysis of data from clinical trials and vaccination studies.

    • Main Results:

    • Peptide-based cancer vaccines are a promising therapeutic approach with positive outcomes in clinical trials.
    • Advancements in sequencing technologies and in silico methods enhance antigen identification.
    • Novel delivery systems and understanding of tumor immune evasion mechanisms are improving vaccine development.

    Conclusions:

    • Peptide-based vaccines represent a significant advancement in cancer immunotherapy.
    • Continued research into neoantigen prediction, delivery methods, and immune evasion is crucial.
    • Peptide vaccines hold considerable promise for future cancer treatment strategies.