Related Experiment Video
Updated: May 5, 2026
08:58
Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
12.3K
Nano-Selenium Alleviates Cd-Induced Chronic Colitis through Intestinal Flora.
Chengdong Zhou1, Shengliang Guo1, Pin Gong1
1School of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Nutrients
|May 11, 2024
Summary
Nano-selenium (nano-Se) effectively reduced intestinal inflammation and protected the gut barrier in mice exposed to cadmium toxicity and colitis. This novel selenium form improved gut microbiota and short-chain fatty acid levels.
Area of Science:
- Environmental Toxicology
- Nutritional Biochemistry
- Gastroenterology
Background:
- Cadmium (Cd) is a toxic environmental contaminant impacting health.
- Selenium (Se) mitigates Cd toxicity and colitis, existing as inorganic and organic forms.
- Nano-selenium (nano-Se) is a novel form with poorly understood effects on Cd-induced enterotoxicity.
Purpose of the Study:
- Investigate nano-Se's impact on mitigating cadmium toxicity.
- Assess nano-Se's role in protecting intestinal barrier integrity.
Main Methods:
- Mice underwent two cycles of chronic colitis induction.
- Exposure involved cadmium (Cd) and nano-selenium for two weeks.
- DSS water was administered for one week post-exposure.
Main Results:
- Nano-Se application lessened colitis severity and colon inflammation.
- Enhanced intestinal flora diversity and fecal short-chain fatty acids (SCFAs) were observed.
- Improved intestinal barrier integrity was a key finding.
Conclusions:
- Nano-Se may reduce intestinal inflammation via microbial regulation.
- Nano-Se protects the intestinal barrier, offering a potential therapeutic strategy.
